Although delta-9-tetrahydrocannabinol (THC) is the most important psychoactive ingredient, other acknowledged compounds with biological action are cannabinol, cannabidiol (CBD), cannabichromene, cannabigerol, tetrahydrocannabivarin, and delta-8-THC. Cannabinoids are a team of 21-carbon-made up of terpenophenolic compounds generated uniquely by Cannabis species (e.g., Cannabis sativa L.). In 1942, Cannabis was eliminated from the U.S.