On the other hand, the GnRH antagonist protocol has a reduced risk of ovarian hyperstimulation syndrome (OHSS), which is a lifestyle-threatening complication. The ensuing prediction of e.g. poor or hyper-reaction to ovarian hyperstimulation establishes the protocol and dosage for ovarian hyperstimulation. It need to get started with reaction prediction by e.g. age, antral follicle depend and degree of anti-Müllerian hormone.