Neurological structures historically appreciated for their roles in panic contain the amygdala, insula and orbitofrontal cortex (OFC). However, the actual connection between the amygdala and the frontal cortex (e.g., prefrontal cortex or the orbitofrontal cortex (OFC)) is not absolutely recognized due to the fact there are scientific studies that propose elevated or lessened exercise in the frontal cortex in individuals who have GAD.