In the 2-generation reproductive toxicity examine in rats, the maternal (systemic) NOAEL was .7 mg/kg/day, primarily based on dystocia, delayed vaginal opening, and greater liver weight at the LOAEL of 5.9 mg/kg/working day. In the rat developmental toxicity review (83-3aYMRID 00163710), dose concentrations of 10, 100, and a thousand mg/kg/day have been administered by way of gavage on days 6-15 of gestation.