In 363, beneath the phrases of a peace treaty, Nisibis was ceded to the Persians, resulting in Ephrem the Syrian, accompanied by a selection of instructors, to leave the School of Nisibis for Edessa even now in Roman territory. He was in favour with the Emperor Justinian, who utilized him in the imperial provider and sent him to Asia Minor to preach amongst the pagans however to be identified spherical Ephesus.