Enthusiasm for its use in POEMS syndrome, having said that, really should be tempered by the adhering to: 1) thalidomide causes peripheral neuropathy in 20% of myeloma people getting the drug 2) thalidomide has been shown to worsen fluid retention in individuals with key systemic amyloidosisref and 3) as a one agent, thalidomide is no a lot more helpful than oral alkylators in patients with plasma mobile disorders.